منابع مشابه
Hedgehog signalling
The Hedgehog (Hh) signalling pathway is one of the key regulators of metazoan development. Hh proteins have been shown to play roles in many developmental processes and have become paradigms for classical morphogens. Dysfunction of the Hh pathway underlies a number of human developmental abnormalities and diseases, making it an important therapeutic target. Interest in Hh signalling thus extend...
متن کاملhedgehog signalling pathway: carcinogenesis and targeted therapy
hedgehog signalling pathway has not only a critical role in cell proliferation, differentiation and tissue polarity at embryonic period but also has a vital role in stem cell proliferation, tissue healing and carcinogenesis. recent research has increased our understanding of this pathway and its relation to other signalling pathways. in addition, a large number of studies confirmed the alterati...
متن کاملGli2, hedgehog and TCR signalling
A structurally and functionally diverse T-cell repertoire is essential for each of the key roles of the adaptive immune system: elimination of foreign pathogens, provision of immunological memory and the maintenance of tolerance to self. T-cells develop in the thymus and then migrate to the periphery where they undergo activation and functional differentiation following contact with cognate ant...
متن کاملHedgehog signalling in liver regeneration
Introduction The adult liver has unique regenerative capabilities. Adult livers generally regenerate fully functional liver cells when injured, unlike other vital adult organs which typically respond to cell loss by forming scar tissue. The mechanisms underlying these differences are not well understood, particularly since adult livers are perfectly capable of scarring. In fact, transient scar ...
متن کاملHedgehog signalling in breast cancer.
Breast cancer is the most common cause of cancer death among women worldwide. In order to improve the treatment of this disease, a more complete understanding of its biological basis is necessary. Since the Hedgehog (Hh) pathway was recently found to be required for growth and propagation of a number of different cancers, we discuss here the possible involvement of this pathway in the normal bi...
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ژورنال
عنوان ژورنال: Nature Reviews Genetics
سال: 2003
ISSN: 1471-0056,1471-0064
DOI: 10.1038/nrg1164